HCID 86677039、化合物 → HCID 178518821、化合物

HRID 927186ノート

反応式

HRID 927186 の反応式
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28](/[CH:39]=[CH:40]/[C:41]2[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[C:43]([F:51])[CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>>[F:51][C:43]1[CH:42]=[C:41]([CH2:40][CH2:39][C:28]2[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=2)[CH:46]=[CH:45][C:44]=1[C:47]([F:50])([F:48])[F:49]

参加物

3

反応物 2

HCID 86677039HCID 86677039、化合物2 回HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

生成物 1

HCID 178518821HCID 178518821、化合物収率 60%

実験手順

Prepared as described for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(E)-2-[3-fluoro-4-(trifluoromethyl)phenyl]ethenyl]pyridazine (Intermediate 79) in 60% yield. The solid was purified by reverse phase chromatography, eluting with 5-100% acetonitrile in water with acid modifier to yield 6-{2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3-dihydropyridazin-3-one in 60% yield.

後処理

  1. customPrepared
  2. customThe solid was purified by reverse phase chromatography
  3. washeluting with 5-100% acetonitrile in water with acid modifier

出典と根拠

ORDレコード
ord-8babf83032c44e1389ba80f2274f3c6b
出典データセット
uspto-grants-2016_03
特許番号
US09290456B2

反応ノート

読み込み中…