関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | 2-Amino-5-nitrobenzoic acid | HCID 12032 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 6-Nitro-2,4(1H,3H)-quinazolinedione | HCID 816982 | 73.2% |
反応手順
A mixture of 2-amino-5-nitrobenzoic acid (0.588 g, 3.23 mmol) and urea (1.164 g, 19.38 mmol) was heated at 200° C. under N2 for 1 h. The mixture was cooled to room temperature and 4 M NaOH was added until pH=14. It was acidified to pH=5.0 via addition of AcOH. The mixture was filtered and the yellow solid was dried to give the title compound (0.49 g, 72.8%) as a yellow solid. MS: m/z 208.1 [M+1]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09290460B2 |
|---|
| 出典データセット | uspto-grants-2016_03 |
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| ORD ID | ord-769710638e4c43b2b24dd08fbb7b2248 |
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| 出典メモ | uspto-grants-2016_03 |
|---|
