Ammonia → HCID 86702436、化合物
反応式
Br[C:2]1[CH:3]=[C:4]([F:12])[CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[CH3:11].[NH3:13]>O>[CH3:11][C:7]1[C:6]2[C:10](=[C:2]([NH2:13])[CH:3]=[C:4]([F:12])[CH:5]=2)[NH:9][CH:8]=1参加物
4
反応条件
- 温度
- 170 °C
実験手順
A mixture of 7-Bromo-5-fluoro-3-methyl-indole (2.5 g), Cu (0.77 g), CuBr (1.57 g) and NH3 (30 mL of a 33% aqueous solution) was heated in an autoclave for 2 h at 170° C. The mixture was diluted with water and extracted with ethyl acetate. The organic phase was dried and the solvent removed to give 3-methyl-5-fluoro-7-amino-indole (1.84 g) as an oil which was used without further purification. UPLC/MS found for C9H9FN2 as (M+H)+ 165.2
後処理
- extractionextracted with ethyl acetate
- customThe organic phase was dried
- customthe solvent removed
出典と根拠
- ORDレコード
- ord-644547ab89c540b89becc227c43d59fb
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09290481B2
反応ノート
読み込み中…