Thiomorpholine → (6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridin-2-yl)-thiomorpholin-4-yl-methanone

反応式

[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[NH:20]1[CH2:25][CH2:24][S:23][CH2:22][CH2:21]1>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([N:20]3[CH2:25][CH2:24][S:23][CH2:22][CH2:21]3)=[O:14])[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:2][CH2:3]1

参加物

反応物 2

HCID 67164Thiomorpholine

HCID 710877336-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid

生成物 1

HCID 71087918(6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridin-2-yl)-thiomorpholin-4-yl-methanone

実験手順

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid (Example 14 a) and thiomorpholine (CAN 123-90-0) as starting materials, MS (LC/MS): 348.1 [M+H]+.

出典と根拠

ORDレコード: ord-cbb0aa10ebd844c88793d72ac8b42a23
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09290451B2

反応ノート

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