1,1-Dimethoxyethyl(dimethyl)amine → HCID 86674739、化合物

HRID 927374ノート

反応式

HRID 927374 の反応式
[NH2:1][C:2](=[S:14])[C:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:5])[CH3:4].CO[C:17](OC)([N:19]([CH3:21])[CH3:20])[CH3:18]>C(Cl)Cl>[C:9]([O:8][C:7](=[O:13])[NH:6][C:3]([CH3:5])([CH3:4])[C:2]([N:1]=[C:17]([N:19]([CH3:21])[CH3:20])[CH3:18])=[S:14])([CH3:12])([CH3:11])[CH3:10]

参加物

4

反応物 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 15186362tert-butyl N-(1-carbamothioyl-1-methylethyl)carbamate

生成物 1

HCID 86674739HCID 86674739、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of tert-butyl 1-amino-2-methyl-1-thioxopropan-2-ylcarbamate (Example 12 b, 0.218 g, 1 mmol) and 1,1-dimethoxy-N,N-dimethylethanamine (CAN 18871-66-4, 0.16 g, 1.2 mmol) in methylene chloride (10 mL) was stirred at room temperature for 24 h. Then it was concentrated to give crude product, which was used directly in the next step without further purification (0.28 g, 98%) as yellow oil; MS (EI): m/e 288.2 [M+H]+.

後処理

  1. concentrationThen it was concentrated
  2. customto give crude product, which
  3. customwas used directly in the next step without further purification (0.28 g, 98%) as yellow oil

出典と根拠

ORDレコード
ord-9340c697d82d41e6a0819b1612966716
出典データセット
uspto-grants-2016_03
特許番号
US09290451B2

反応ノート

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