Hydrochloric Acid → 5-Methyl-6-sulfo-pyridine-2-carboxylic acid methyl ester

HRID 927385ノート

反応式

HRID 927385 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([OH:14])=[O:13])=[N:6][C:7]=1[S:8]([OH:11])(=[O:10])=[O:9].Cl.[CH3:16]O>O1CCOCC1>[CH3:16][O:13][C:12]([C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[C:7]([S:8]([OH:11])(=[O:9])=[O:10])[N:6]=1)=[O:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 866747445-Methyl-6-sulfo-pyridine-2-carboxylic acid

生成物 1

HCID 866747455-Methyl-6-sulfo-pyridine-2-carboxylic acid methyl ester

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a mixture of 5-methyl-6-sulfo-pyridine-2-carboxylic acid (0.8 g, 3.69 mmol) in methanol (20 mL) was added 4 N hydrogen chloride in dioxane (8 mL). The mixture was stirred overnight at room temperature. Undissolved solid was filtered off, and the filtrate was concentrated to give the product as yellow solid 0.5 g; MS (EI): m/e=232.0 [M+H]+.

後処理

  1. filtrationwas filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-cd1771dfcdf04cd49d0935621885f1a7
出典データセット
uspto-grants-2016_03
特許番号
US09290451B2

反応ノート

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