5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide
反応式
C1(C2C=CC(C(O)=O)=NC=2OCC2CC2)CC1.[CH:18]1([CH2:21][C@H:22]([NH:28][C:29]([C:31]2[CH:36]=[CH:35][C:34]([CH:37]3CCO[CH2:39][CH2:38]3)=[C:33]([O:43][CH2:44][CH:45]3[CH2:47][CH2:46]3)[N:32]=2)=[O:30])[C:23]2[S:24][CH:25]=[CH:26][N:27]=2)[CH2:20][CH2:19]1>>[CH:18]1([CH2:21][C@H:22]([NH:28][C:29]([C:31]2[CH:36]=[CH:35][C:34]([CH:37]3[CH2:39][CH2:38]3)=[C:33]([O:43][CH2:44][CH:45]3[CH2:47][CH2:46]3)[N:32]=2)=[O:30])[C:23]2[S:24][CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:20]1参加物
3
反応物 2
生成物 1
実験手順
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and (S)-2-cyclopropyl-1-thiazol-2-yl-ethylamine (Example 59 b) as starting materials, MS (LC/MS): m/e=384.3 [M+H]+.