6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-amide

HRID 927670ノート

反応式

HRID 927670 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[C:15]([F:18])([F:17])[F:16])[CH2:3][CH2:2]1.C1(N(C2N=C(C)ON=2)C)CC1.[CH:30]1([CH2:33][C@H:34]([NH2:41])[C:35]2[N:39]=[C:38]([CH3:40])[O:37][N:36]=2)[CH2:32]C1>>[CH:33]1([CH:34]([NH:41][C:12]([C:10]2[CH:9]=[CH:8][C:7]([C:15]([F:18])([F:17])[F:16])=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[C:35]2[N:39]=[C:38]([CH3:40])[O:37][N:36]=2)[CH2:30][CH2:32]1

参加物

4

反応物 3

HCID 710874576-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acidHCID 86674748(S)-2-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamineHCID 86674778Cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methylamine

生成物 1

HCID 711056606-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Example 113 d) and cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methylamine (which can e.g. be prepared in a similar manner than (S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (Example 38 e)) as starting materials, MS (EI): m/e=397.0 [M+H]+.

出典と根拠

ORDレコード
ord-3d53dacb3df041ca9220c65bdcecd688
出典データセット
uspto-grants-2016_03
特許番号
US09290451B2

反応ノート

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