(2S)-2-amino-N,4,4-trimethyl-pentanamide → 6-(Tetrahydro-pyran-4-ylmethoxy)-5-trifluoromethyl-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

HRID 927672

反応式

HRID 927672 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[N:14]=[C:13]([C:15]([OH:17])=O)[CH:12]=[CH:11][C:10]=2[C:18]([F:21])([F:20])[F:19])[CH2:3][CH2:2]1.[NH2:22][C@@H:23]([CH2:28][C:29]([CH3:32])([CH3:31])[CH3:30])[C:24]([NH:26][CH3:27])=[O:25]>>[CH3:30][C:29]([CH3:32])([CH3:31])[CH2:28][C@H:23]([NH:22][C:15]([C:13]1[CH:12]=[CH:11][C:10]([C:18]([F:21])([F:20])[F:19])=[C:9]([O:8][CH2:7][CH:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[N:14]=1)=[O:17])[C:24](=[O:25])[NH:26][CH3:27]

参加物

3

反応物 2

HCID 57635521(2S)-2-amino-N,4,4-trimethyl-pentanamideHCID 710873886-((Tetrahydro-2H-pyran-4-yl)methoxy)-5-(trifluoromethyl)picolinic acid

生成物 1

HCID 711056596-(Tetrahydro-pyran-4-ylmethoxy)-5-trifluoromethyl-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 6-((tetrahydro-2H-pyran-4-yl)methoxy)-5-(trifluoromethyl)picolinic acid and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials, MS (EI): m/e=446.4 [M+H]+.

出典と根拠

ORDレコード
ord-7a89dfa1362145eda3c7636d882b02fb
出典データセット
uspto-grants-2016_03
特許番号
US09290451B2

関連ノート

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