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HRID 927708作成日：2026年10月25日

3,3-Difluoroazetidine hydrochloride → 2-{[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester

https://huagongshe.com/reaction/927708

反応式

関与物質

役割名称HCID仕込み量
反応物3,3-Difluoroazetidine hydrochlorideHCID 2758247—
反応物2-[(5-Bromo-6-cyclopropylmethoxy-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl esterHCID 71087280—
生成物2-{[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl esterHCID 71087467—

反応手順

The title compound was synthesized in analogy to the procedure described in Example 69 a, using ethyl 2-(5-bromo-6-(cyclopropylmethoxy)picolinamido)-2-ethylbutanoate (Example 265) and 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) as starting materials. MS (EI): m/e=426.0 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09290451B2
出典データセットuspto-grants-2016_03
ORD IDord-467a22096d2f4eb98c72d6897f9c1892
出典メモuspto-grants-2016_03