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Sodium Hydroxide → 2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-2-ethylbutanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-{[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester | HCID 71087467 | — |
| 生成物 | 2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-2-ethylbutanoic acid | HCID 71087739 | — |
反応手順
In analogy to the procedure described in Example 252 b), 2-{[6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester (Example 266) was treated with sodium hydroxide to give the title compound as colorless oil. MS: 396.2 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09290451B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-b352a4b4ebf043b68aa73a065c2d7b13 |
| 出典メモ | uspto-grants-2016_03 |