methyl (1aRS,7bSR)-5-(2,2-dimethylpropionylamino)-1,1-difluoro-1,1a,2,7b-tetrahydro-cyclopropa[c]chromene-4-carboxylate → Methyl (1aRS,7bSR)-5-amino-1,1-difluoro-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylate
反応式
NC1C(C(OC)=O)=C2C(C3CC3CO2)=CC=1.CC(C)(C)C([NH:21][C:22]1[C:31]([C:32]([O:34][CH3:35])=[O:33])=[C:30]2[C:25]([CH:26]3[C:36]([F:38])([F:37])[CH:27]3[CH2:28][O:29]2)=[CH:24][CH:23]=1)=O>>[NH2:21][C:22]1[C:31]([C:32]([O:34][CH3:35])=[O:33])=[C:30]2[C:25]([CH:26]3[C:36]([F:38])([F:37])[CH:27]3[CH2:28][O:29]2)=[CH:24][CH:23]=1参加物
3
反応物 2
生成物 1
実験手順
Prepared by proceeding in a similar manner to Intermediate 42, starting from methyl (1aRS,7bSR)-5-(2,2-dimethylpropionylamino)-1,1-difluoro-1,1a,2,7b-tetrahydro-cyclopropa[c]chromene-4-carboxylate (Intermediate 62) as an off white solid.