tert-butyl (2R)-2-(cyanomethyl)pyrrolidine-1-carboxylate → (R)-2-(Pyrrolidin-2-yl)acetonitrile hydrochloride

反応式

[ClH:1].[NH:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][C:8]#[N:9].C(C[C@H]1CCCN1C(OC(C)(C)C)=O)#N>>[ClH:1].[NH:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[CH2:7][C:8]#[N:9]

参加物

反応物 2

HCID 10727173tert-butyl (2R)-2-(cyanomethyl)pyrrolidine-1-carboxylate2 回

HCID 86713338(S)-2-(Pyrrolidin-2-yl)acetonitrile hydrochloride

生成物 1

HCID 86713341(R)-2-(Pyrrolidin-2-yl)acetonitrile hydrochloride

実験手順

Prepared by proceeding in a similar manner to Intermediate 138, starting from tert-butyl (R)-2-cyanomethylpyrrolidine-1-carboxylate (Intermediate 144) and used without further characterisation.

後処理

customPrepared

出典と根拠

ORDレコード: ord-ba1b5a73778c47a1b85026918b8ff7f3
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09290472B2

反応ノート

読み込み中…