tert-butyl (S)-3-(2-chlorosulfonyl-5-fluorobenzyloxy)pyrrolidine-1-carboxylate → tert-butyl (S)-3-[(1aR,7bS)-5-fluoro-2-(4-methoxycarbonyl-1,1a,2,7b-tetrahydro-cyclopropa[c]chromen-5-ylsulfamoyl)benzyloxy]pyrrolidine-1-carboxylate

反応式

Cl[S:2]([C:5]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:6]=1[CH2:7][O:8][C@H:9]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10]1)(=[O:4])=[O:3].[NH2:26][C:27]1[C:36]([C:37]([O:39][CH3:40])=[O:38])=[C:35]2[C:30]([C@H:31]3[CH2:41][C@H:32]3[CH2:33][O:34]2)=[CH:29][CH:28]=1>C(Cl)Cl>[F:25][C:22]1[CH:23]=[CH:24][C:5]([S:2](=[O:4])(=[O:3])[NH:26][C:27]2[CH:28]=[CH:29][C:30]3[C@H:31]4[CH2:41][C@H:32]4[CH2:33][O:34][C:35]=3[C:36]=2[C:37]([O:39][CH3:40])=[O:38])=[C:6]([CH:21]=1)[CH2:7][O:8][C@H:9]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10]1