Hydrochloric Acid → 3-[1-(3-Fluorophenyl)methylidene]piperidine hydrochloride

HRID 928079ノート

反応式

HRID 928079 の反応式
[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]2[CH2:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]2)[CH:6]=[CH:7][CH:8]=1>O1CCOCC1.CCOCC>[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11]2)[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86713375Tert-butyl 3-[1-(3-fluorophenyl)methylidene]piperidine-1-carboxylate2 回

生成物 1

HCID 709838913-[1-(3-Fluorophenyl)methylidene]piperidine hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of HCl in dioxane (4M, 30 mL) was added to a solution of tert-butyl 3-[1-(3-fluorophenyl)methylidene]piperidine-1-carboxylate (Intermediate 227, 2.38 g) in ether (30 mL) and the mixture was stirred at room temperature for 5 hours. The mixture was concentrated in vacuo and the residue was treated with ether. The solid was collected by filtration, washed with ether and dried under vacuum to give 3-[1-(3-fluorophenyl)methylidene]piperidine hydrochloride (1.64 g).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. additionthe residue was treated with ether
  3. filtrationThe solid was collected by filtration
  4. washwashed with ether
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-1444adab56f54a87a3b0ccc60405ac1f
出典データセット
uspto-grants-2016_03
特許番号
US09290472B2

反応ノート

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