Ammonium Hydroxide → 3-(5-Bromo-2-fluorobenzoylamino)pyrazine-2-carboxamide

HRID 928261

反応式

HRID 928261 の反応式
C[O:2][C:3]([C:5]1[C:10]([NH:11][C:12](=[O:21])[C:13]2[CH:18]=[C:17]([Br:19])[CH:16]=[CH:15][C:14]=2[F:20])=[N:9][CH:8]=[CH:7][N:6]=1)=O.[NH4+:22].[OH-]>C(O)C>[Br:19][C:17]1[CH:16]=[CH:15][C:14]([F:20])=[C:13]([CH:18]=1)[C:12]([NH:11][C:10]1[C:5]([C:3]([NH2:22])=[O:2])=[N:6][CH:7]=[CH:8][N:9]=1)=[O:21]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 577423823-(5-bromo-2-fluorobenzoylamino)pyrazine-2-carboxylic Acid Methyl Ester

生成物 1

HCID 577423843-(5-Bromo-2-fluorobenzoylamino)pyrazine-2-carboxamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3-(5-bromo-2-fluorobenzoylamino)pyrazine-2-carboxylic acid methyl ester 102 (2.6 g, 7.34 mmol) and NH4OH (15 mL) in ethanol (50 mL) was heated at reflux for 10 min. Then, the reaction mixture was cooled at room temperature and the precipitate was filtered off, washed with ethanol and ether to give 2.1 g of the title product 103 as a white powder (LCMS analysis).

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 10 min
  3. filtrationthe precipitate was filtered off
  4. washwashed with ethanol and ether

出典と根拠

ORDレコード
ord-69d79c10a6a24885b5886e0cebd64be8
出典データセット
uspto-grants-2016_03
特許番号
US09290502B2

関連ノート

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