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Pyrrolidine → 2-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 2-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one | HCID 136109958 | — |
| 生成物 | 2-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one | HCID 136109957 | — |
反応手順
A solution of 2-(5-bromo-2-fluorophenyl)pteridin-4-one 104 in pyrrolidine was heated in a microwave cavity (Power=270 W, Temp=110° C.) for 12 min. The pyrrolidine was evaporated, then residue partitioned between NaHCO3 0.5 N and CH2Cl2, dried (Na2SO4) and evaporated. Trituration in Et2O afforded the title product 110 as a yellow powder (LCMS analysis).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09290502B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-bcd291c8f63c4093805a96ab93d1a512 |
| 出典メモ | uspto-grants-2016_03 |