2-(5-Bromo-2-fluorophenyl)-4-(4-pyridylamino)pteridine → 4-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine

HRID 928271

反応式

HRID 928271 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:8]2[NH:17][C:16](=O)[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[N:9]=2)[CH:7]=1.[CH2:20]([NH:24][C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1)[CH2:21][CH2:22][CH3:23].BrC1C=CC(F)=C(C2N=C(NC3C=CN=CC=3)C3C(=NC=CN=3)N=2)C=1>>[CH2:20]([N:24]([C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1)[C:16]1[C:15]2[C:10](=[N:11][CH:12]=[CH:13][N:14]=2)[N:9]=[C:8]([C:6]2[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[F:19])[N:17]=1)[CH2:21][CH2:22][CH3:23]

参加物

4

反応物 3

HCID 119622182-(5-Bromo-2-fluorophenyl)-4-(4-pyridylamino)pteridineHCID 14322667N-Butylpyridin-4-amineHCID 1361099582-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one

生成物 1

HCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine

実験手順

The title product was synthesized by reaction of the 2-(5-bromo-2-fluorophenyl)-pteridin-4-one 104 with 4-butylaminopyridine 113 following the procedure described for 4-(4-pyridylamino)-2-(5-bromo-2-fluorophenyl)pteridine 1 (LCMS analysis).

出典と根拠

ORDレコード
ord-899f8447edbc4744b1725f8250143c7f
出典データセット
uspto-grants-2016_03
特許番号
US09290502B2

関連ノート

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