4-(Methylamino)pyridine → 2-(5-Bromo-2-fluorophenyl)-4-[(methyl)(4-pyridyl)amino]pteridine

HRID 928273

反応式

HRID 928273 の反応式
BrC1C=CC(F)=C(C2NC(=O)C3C(=NC=CN=3)N=2)C=1.CNC1C=CN=CC=1.[CH2:28]([N:32]([C:51]1[CH:56]=[CH:55][N:54]=[CH:53][CH:52]=1)[C:33]1[C:42]2[C:37](=[N:38][CH:39]=[CH:40][N:41]=2)[N:36]=[C:35]([C:43]2[CH:48]=[C:47]([Br:49])[CH:46]=[CH:45][C:44]=2[F:50])[N:34]=1)CCC>>[Br:49][C:47]1[CH:46]=[CH:45][C:44]([F:50])=[C:43]([C:35]2[N:34]=[C:33]([N:32]([CH3:28])[C:51]3[CH:52]=[CH:53][N:54]=[CH:55][CH:56]=3)[C:42]3[C:37](=[N:38][CH:39]=[CH:40][N:41]=3)[N:36]=2)[CH:48]=1

参加物

4

反応物 3

HCID 1230984-(Methylamino)pyridineHCID 444320664-[(Butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridineHCID 1361099582-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one

生成物 1

HCID 444320652-(5-Bromo-2-fluorophenyl)-4-[(methyl)(4-pyridyl)amino]pteridine

実験手順

The title product was synthesized by reaction of the 2-(5-bromo-2-fluorophenyl)-pteridin-4-one 104 with 4-(methylamino)pyridine following the procedure described for 4-[(butyl)(4-pyridyl)amino]-2-(5-bromo-2-fluorophenyl)pteridine 3.

出典と根拠

ORDレコード
ord-863e79a7ef3344c6a20e732c70f5eb52
出典データセット
uspto-grants-2016_03
特許番号
US09290502B2

関連ノート

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