Lithium hydroxide, monohydrate → 3-Benzyl-1,2,4-oxadiazole-5-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:7]=1)=[O:5])C.O.[OH-].[Li+]>CO.O>[CH2:11]([C:8]1[N:7]=[C:6]([C:4]([OH:5])=[O:3])[O:10][N:9]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1参加物
5
実験手順
A mixture of 3-Benzyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (360 mg, 1.6 mmol) and lithiumhydroxide-hydrate (65 mg, 1.6 mmol) in 10 mL MeOH and 5 mL water was stirred at room temperature for 1 h. The mixture was evaporated in vacuo to yield the crude product which was used in the next step without further purification.
後処理
- customThe mixture was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-f8df3757be9f4796900ea61f8a839c0e
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09290485B2
反応ノート
読み込み中…