1-(4-Pyrazol-1-ylmethyl-benzyl)-1H-imidazole-4-carboxylic acid methyl ester → 1-(4-Pyrazol-1-ylmethyl-benzyl)-1H-imidazole-4-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][N:18]3[CH:22]=[CH:21][CH:20]=[N:19]3)=[CH:13][CH:12]=2)[CH:9]=1)=[O:4]>CO.O>[N:18]1([CH2:17][C:14]2[CH:15]=[CH:16][C:11]([CH2:10][N:8]3[CH:9]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=[CH:7]3)=[CH:12][CH:13]=2)[CH:22]=[CH:21][CH:20]=[N:19]1参加物
4
実験手順
A mixture of 1-(4-Pyrazol-1-ylmethyl-benzyl)-1H-imidazole-4-carboxylic acid methyl ester (730 mg, 2.5 mmol) and lithiumhydroxyde-hydrate (210 mg, 4.9 mmol) in 10 mL MeOH and 5 mL water was stirred at room temperature for 3 h. The mixture was evaporated in vacuo, the residue was acidified with 1 N aq. HCl and lyophilised to yield the crude product which was used in the next step without further purification. LCMS (method A) RtA=0.412 min; [M+H]+=283.0.