Toluene → Methyl 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylate
反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH3:14].[C:15]1(C)C=CC=CC=1>CO>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([O:13][CH3:15])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH3:14]参加物
4
実験手順
To a suspension of 1,2-Dimethyl-1H-benzo[d]imidazole-5-carboxylic acid (crude, 2.54 g, approx. 9.35 mmol) in MeOH (15.5 ml)/toluene (78 ml) Trimethylsilyldiazomethane (2 M solution in hexane, 7.0 ml, 14 mmol) was added at 0-10° C. The reaction mixture was stirred at it for 1 hour. The reaction mixture was evaporated under reduced pressure. The residue was taken up in DCM, Remaining insoluble solid was filtered off. The filtrate was evaporated again to dryness to afford crude Methyl 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylate
後処理
- additionwas added at 0-10° C
- customThe reaction mixture was evaporated under reduced pressure
- filtrationwas filtered off
- customThe filtrate was evaporated again to dryness
出典と根拠
- ORDレコード
- ord-e526c639768d4100a852bb5e94a042d8
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09290485B2
反応ノート
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