3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline → (4-Chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(4-chlorophenyl)methanone

HRID 928749

反応式

HRID 928749 の反応式
N1(C2C=CC(CC3[C:12]([O:24]C)=NC4C(C=3Cl)=CC(Br)=CC=4C)=CC=2)C=CC=N1.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]([C:37]2[CH:38]=[C:39]3[C:44](=[CH:45][CH:46]=2)[N:43]=[C:42](Cl)[C:41]([CH2:48][C:49]2[CH:54]=[CH:53][C:52]([S:55]([CH3:58])(=[O:57])=[O:56])=[CH:51][CH:50]=2)=[C:40]3[Cl:59])=[O:36])=[CH:31][CH:30]=1.N1(C2C=CC(CC3C(OC)=NC4C(C=3Cl)=CC(Br)=CC=4)=CC=2)C=CC=N1>>[Cl:59][C:40]1[C:39]2[C:44](=[CH:45][CH:46]=[C:37]([C:35]([C:32]3[CH:33]=[CH:34][C:29]([Cl:28])=[CH:30][CH:31]=3)=[O:36])[CH:38]=2)[N:43]=[C:42]([O:24][CH3:12])[C:41]=1[CH2:48][C:49]1[CH:50]=[CH:51][C:52]([S:55]([CH3:58])(=[O:57])=[O:56])=[CH:53][CH:54]=1

参加物

4

反応物 3

HCID 867155963-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline2 回HCID 867155993-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinolineHCID 86715602(4-Chlorophenyl)(2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)methanone

生成物 1

HCID 86715601(4-Chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(4-chlorophenyl)methanone

実験手順

The title compound was prepared by substituting 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline (Intermediate 6: step c) with (4-chlorophenyl)(2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)methanone (Intermediate 22: step a) then following the procedure described for the preparation of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline (Intermediate 16).

出典と根拠

ORDレコード
ord-7fca3fa0efc54a148603269c84b79ceb
出典データセット
uspto-grants-2016_03
特許番号
US09290476B2

関連ノート

読み込み中…