3-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinoline → 3-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-4-chloro-2-methoxyquinoline

HRID 928750

反応式

HRID 928750 の反応式
N1(C2C=CC(C[C:11]3[C:12]([O:24][CH3:25])=[N:13][C:14]4[C:19]([C:20]=3[Cl:21])=[CH:18][C:17]([Br:22])=[CH:16][C:15]=4C)=CC=2)C=CC=N1.[S:28]1[C:32]([CH2:33]C2C(Cl)=NC3C(C=2Cl)=CC(Br)=CC=3)=[CH:31][C:30]2[CH:47]=[CH:48][CH:49]=[CH:50][C:29]1=2.N1(C2C=CC(CC3C(OC)=NC4C(C=3Cl)=CC(Br)=CC=4)=CC=2)C=CC=N1>>[S:28]1[C:32]([CH2:33][C:11]2[C:12]([O:24][CH3:25])=[N:13][C:14]3[C:19]([C:20]=2[Cl:21])=[CH:18][C:17]([Br:22])=[CH:16][CH:15]=3)=[CH:31][C:30]2[CH:47]=[CH:48][CH:49]=[CH:50][C:29]1=2

参加物

4

反応物 3

HCID 867155913-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinoline2 回HCID 867155963-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline2 回HCID 867155993-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinoline

生成物 1

HCID 867156033-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-4-chloro-2-methoxyquinoline

実験手順

The title compound was prepared by substituting 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline (Intermediate 6: step c) with 3-(benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinoline (Intermediate 10: step c) then following the procedure described for the preparation of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline (Intermediate 16).

出典と根拠

ORDレコード
ord-7e3d2bdab962403c81c92daba58f19bd
出典データセット
uspto-grants-2016_03
特許番号
US09290476B2

関連ノート

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