tert-Butyldimethylsilyl chloride → 2-(3-Tert-butyldimethylsilyloxyphenyl)pyridine

反応式

[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[Si:14](Cl)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15]>>[Si:14]([O:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15]

参加物

反応物 2

HCID 28928tert-Butyldimethylsilyl chloride

HCID 134170943-(Pyridin-2-yl)phenol

生成物 1

HCID 497663092-(3-Tert-butyldimethylsilyloxyphenyl)pyridine

実験手順

Then, 2-(3-hydroxyphenyl)pyridine is treated with tert-butyldimethylsilyl chloride (TBDMSCl) to protect the OH group with a tert-butyldimethylsilyl group and give 2-(3-tert-butyldimethylsilyloxyphenyl)pyridine according to scheme (3).

出典と根拠

ORDレコード: ord-196847f24e084e8b9a80edf10647037f
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09290692B2

反応ノート

読み込み中…