Phosphorus oxychloride → HCID 50914394、化合物

反応式

[CH3:1][C:2]1([CH3:15])[O:6][C@@H:5]([CH2:7][C:8]2([S:11]([O-])(=[O:13])=[O:12])[CH2:10][CH2:9]2)[CH2:4][O:3]1.[Na+].P(Cl)(Cl)([Cl:19])=O>>[CH3:1][C:2]1([CH3:15])[O:6][C@@H:5]([CH2:7][C:8]2([S:11]([Cl:19])(=[O:13])=[O:12])[CH2:10][CH2:9]2)[CH2:4][O:3]1

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 86698215HCID 86698215、化合物

生成物 1

HCID 50914394HCID 50914394、化合物

実験手順

A solution of sodium (S)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonate (1 eq) and phosphoryl trichloride (POCl3, 0.7 mL/mmol) is heated at 80° C. for 1 hour. The reaction mixture is cooled to room temperature, poured onto ice, stirred for 30 minutes and extracted with chloroform (2×). The combined organic extracts are dried (MgSO4) and concentrated under reduced pressure.

後処理

additionpoured onto ice
extractionextracted with chloroform (2×)
dry with materialThe combined organic extracts are dried (MgSO4)
concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード: ord-3b4ce330ff7c4936bf52e4193af16833
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09296686B2

反応ノート

読み込み中…

参加物