Water → 2-Bromo-4-(tert-butyl)-1-((2-methoxyethoxy)methoxy)benzene

HRID 929553

反応式

HRID 929553 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[OH:12].C(N(CC)CC)C.[CH3:20][O:21][CH2:22][CH2:23][O:24][CH2:25]Cl.O>ClCCl>[Br:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:9])([CH3:11])[CH3:10])[CH:5]=[CH:4][C:3]=1[O:12][CH2:20][O:21][CH2:22][CH2:23][O:24][CH3:25]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 751472-Bromo-4-tert-butylphenol2 回HCID 775901-(Chloromethoxy)-2-methoxyethane

生成物 1

HCID 867185612-Bromo-4-(tert-butyl)-1-((2-methoxyethoxy)methoxy)benzene収率 72.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-bromo-4-(tert-butyl)phenol [Intermediate 1, Step 1] (5.0 g, 21.8 mmol) and triethylamine (4.4 g, 43.5 mmol) in anhydrous dichloromethane (20 mL) at room temperature under nitrogen was added dropwise 2-methoxyethoxymethyl chloride (2.5 mL, 21.9 mmol) and the reaction mixture stirred overnight. The reaction mixture was poured into water (100 mL), the organic phase separated, dried (MgSO4), filtered and concentrated under reduced pressure to give 2-bromo-4-(tert-butyl)-1-((2-methoxyethoxy)methoxy)benzene (5.0 g, 72% yield).

後処理

  1. customthe organic phase separated
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-db6d0b3bb13141bfb824d99a6b3398f6
出典データセット
uspto-grants-2016_03
特許番号
US09296696B2

関連ノート

読み込み中…