3,4-Dichlorobenzeneboronic acid → 3',4'-Dichloro-5-(trifluoromethyl)-[1,1'-biphenyl]-2-ol

反応式

C(C1C=C(C=O)C(O)=C(C2C=CC(OC(F)(F)F)=CC=2)C=1)(C)(C)C.Br[C:26]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:27]=1[OH:36].[Cl:37][C:38]1[CH:39]=[C:40](B(O)O)[CH:41]=[CH:42][C:43]=1[Cl:44]>>[Cl:37][C:38]1[CH:39]=[C:40]([C:26]2[C:27]([OH:36])=[CH:28][CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=2)[CH:41]=[CH:42][C:43]=1[Cl:44]

参加物

反応物 3

HCID 27343303,4-Dichlorobenzeneboronic acid

HCID 27611682-Bromo-4-(trifluoromethyl)phenol

HCID 867187195-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehyde

生成物 1

HCID 867187433',4'-Dichloro-5-(trifluoromethyl)-[1,1'-biphenyl]-2-ol

実験手順

3′,4′-Dichloro-5-(trifluoromethyl)-[1,1′-biphenyl]-2-ol was prepared as a yellow oil using the procedure described in Intermediate 5 from 2-bromo-4-(trifluoromethyl)phenol (Tetrahedron 2003, 59, 6545) and 3,4-dichlorophenylboronic acid.

出典と根拠

ORDレコード: ord-b6850eb4447d459da981da70449c2aeb
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09296696B2

反応ノート

読み込み中…

参加物