Ammonia → 3-(4-Hydroxy-phenyl)-isoxazole-5-carboxylic acid amide

HRID 929752ノート

反応式

HRID 929752 の反応式
C([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[CH:7]=1)=O)C.[NH3:18]>CCO>[OH:17][C:14]1[CH:15]=[CH:16][C:11]([C:8]2[CH:7]=[C:6]([C:4]([NH2:18])=[O:3])[O:10][N:9]=2)=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 136133842Ethyl 3-(4-hydroxyphenyl)isoxazole-5-carboxylate2 回

生成物 1

HCID 1364912503-(4-Hydroxy-phenyl)-isoxazole-5-carboxylic acid amide収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Crude 3-(4-hydroxy-phenyl)-isoxazole-5-carboxylic acid ethyl ester (which may be prepared as described in Preparation of Intermediate 1; 1.9 g, 8.15 mmol) was taken up in a solution of EtOH saturated with NH3. The mixture was stirred overnight at room temperature under nitrogen. The solvent was evaporated to give 3-(4-hydroxy-phenyl)-isoxazole-5-carboxylic acid amide (1.17 g, 70%) as a flaky white powder.

後処理

  1. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-4136bbf102ee41da839f6af865efcdb8
出典データセット
uspto-grants-2016_03
特許番号
US09296711B2

反応ノート

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