3-(Bromomethyl)-2-chloropyridine → 3-[4-(2-Chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

HRID 929759ノート

反応式

HRID 929759 の反応式
[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[CH:7]=1)=[O:5])[CH3:2].Br[CH2:19][C:20]1[C:21]([Cl:26])=[N:22][CH:23]=[CH:24][CH:25]=1>>[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:19][C:20]3[C:21]([Cl:26])=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:15][CH:16]=2)[CH:7]=1)=[O:5])[CH3:2]

参加物

3

反応物 2

HCID 189310283-(Bromomethyl)-2-chloropyridineHCID 136133842Ethyl 3-(4-hydroxyphenyl)isoxazole-5-carboxylate2 回

生成物 1

HCID 902025533-[4-(2-Chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

実験手順

3-(4-Hydroxy-phenyl)-isoxazole-5-carboxylic acid ethyl ester (which may be prepared as described in Preparation of Intermediate 1) and 3-bromomethyl-2-chloro-pyridine (which may be prepared as described in Selby, T. P. and Winters, M. P. U.S. Pat. No. 5,739,326 Column 19) were reacted using conditions similar to those described for Preparation of Intermediate 24 to give 3-[4-(2-chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester.

後処理

  1. custom5,739,326 Column 19) were reacted

出典と根拠

ORDレコード
ord-7d4d68a38fee4b21b104ed3e45d58398
出典データセット
uspto-grants-2016_03
特許番号
US09296711B2

反応ノート

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