3-Hydrazinylpyridine hydrochloride → 5-(3-Bromo-5-methoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid
反応式
[Li].[Br:2][C:3]1[CH:4]=[C:5]([C:11]([O-])=[CH:12][C:13](=O)[C:14]([O:16]CC)=[O:15])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(O)=O)C=2)C=C(F)C=1.Cl.[N:44]1[CH:49]=[CH:48][CH:47]=[C:46]([NH:50][NH2:51])[CH:45]=1>>[Br:2][C:3]1[CH:4]=[C:5]([C:11]2[N:50]([C:46]3[CH:45]=[N:44][CH:49]=[CH:48][CH:47]=3)[N:51]=[C:13]([C:14]([OH:16])=[O:15])[CH:12]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1参加物
4
反応物 3
生成物 1
実験手順
500 mg (1.19 mmol) of the compound of Example 6A is reacted analogously to the synthesis of the compound of Example 20A with 260 mg (1.79 mmol) of 3-pyridylhydrazine hydrochloride. After hydrolysis, 240 mg (54% of theory) of the title compound is obtained.