5-Cyanopyridine-2-carboxylic acid → N-(5-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-5-cyanopicolinamide

HRID 930373ノート

反応式

HRID 930373 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]([OH:11])=O)=[N:7][CH:8]=1)#[N:2].[NH2:12][C:13]1[CH:14]=[C:15]([C@:20]2([CH2:31][F:32])[CH2:25][C@@H:24]([C:26]([F:29])([F:28])[F:27])[O:23][C:22]([NH2:30])=[N:21]2)[C:16]([F:19])=[N:17][CH:18]=1>>[NH2:30][C:22]1[O:23][C@H:24]([C:26]([F:27])([F:29])[F:28])[CH2:25][C@:20]([C:15]2[CH:14]=[C:13]([NH:12][C:9](=[O:11])[C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][N:7]=3)[CH:18]=[N:17][C:16]=2[F:19])([CH2:31][F:32])[N:21]=1

参加物

3

反応物 2

HCID 124007345-Cyanopyridine-2-carboxylic acidHCID 86732195(4S,6S)-4-(5-amino-2-fluoropyridin-3-yl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

生成物 1

HCID 86732199N-(5-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-5-cyanopicolinamide

実験手順

The title compound was synthesized using procedures analogous to those described in Method H Step 2 (Example 66) above, but using 5-cyano-picolinic acid and (4S,6S)-4-(5-amino-2-fluoropyridin-3-yl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (12k, as described in Example 138, method S). MS m/z=441.0 [M+H]+. Calculated for C18H13F5N6O2: 440.3

出典と根拠

ORDレコード
ord-2c460ce09f054676804dea89666cbfdb
出典データセット
uspto-grants-2016_03
特許番号
US09296734B2

反応ノート

読み込み中…