関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 5-Chloropyrido[3,4-b]pyrazin-2(1H)-one | HCID 86715742 | — |
| 生成物 | 2,5-Dichloropyrido[3,4-b]pyrazine | HCID 86715743 | 92.4% |
反応手順
A suspension of 5-chloropyrido[3,4-b]pyrazin-2(1H)-one (0.57 g, 3.14 mmol) in phosphorus oxychloride (10.24 mL, 110 mmol) was stirred at 110° C. for two hours, and then concentrated. The residue was dissolved in DCM, washed with saturated sodium bicarbonate, dried over anhydrous sodium sulfate, filtered, and concentrated to afford the title compound (580 mg, 2.90 mmol). MS m/z=200 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09296734B2 |
|---|
| 出典データセット | uspto-grants-2016_03 |
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| ORD ID | ord-cadff68031f84708a62f698751562d34 |
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| 出典メモ | uspto-grants-2016_03 |
|---|
