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HRID 930705作成日：2026年10月25日

4-(6-(Trifluoromethyl)pyridazin-3-yl)pyridin-2(1H)-one → tert-Butyl 7-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

https://huagongshe.com/reaction/930705

反応式

関与物質

役割名称HCID仕込み量
反応物4-(6-(Trifluoromethyl)pyridazin-3-yl)pyridin-2(1H)-oneHCID 57950262—
反応物tert-Butyl 7-bromo-5-(triisopropylsilyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylateHCID 57950390—
生成物tert-Butyl 7-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylateHCID 5795044930.7%

反応手順

tert-Butyl 7-bromo-5-(triisopropylsilyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (260 mg, 0.51 mmol) and 4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-2(1H)-one (123 mg, 0.510 mmol) were reacted according to the procedure of Example 30 (step g) to provide the title compound (80 mg, 30%) as a yellow solid: ESI MS m/z 512 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09296743B2
出典データセットuspto-grants-2016_03
ORD IDord-caa77cd8e430429eb8c416538de5a958
出典メモuspto-grants-2016_03