Triphenylphosphine → 8-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

反応式

[Cl:1][C:2]1[CH:7]=[C:6]([N:8]([CH:13]2[CH2:15][CH2:14]2)[CH2:9][CH2:10][CH2:11]O)[NH:5][C:4](=[O:16])[N:3]=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[C:6]2[N:8]([CH:13]3[CH2:15][CH2:14]3)[CH2:9][CH2:10][CH2:11][N:5]2[C:4](=[O:16])[N:3]=1

参加物

反応物 3

HCID 11776Triphenylphosphine

HCID 5363146Diisopropyl azodicarboxylate

HCID 178517809HCID 178517809、化合物

生成物 1

HCID 903065708-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

実験手順

To a solution of 4-chloro-6-(cyclopropyl(3-hydroxypropyl)amino) pyrimidin-2(1H)-one (2 g, 8.21 mmol) in tretrahydrofuran (20 mL) were added DIAD (2.394 mL, 12.31 mmol) and triphenylphosphine (3.23 g, 12.31 mmol) at r.t., stirred for 3 h, and concentrated. Purification via C-18 column, and afforded the title compound as a white solid.