Sodium Chloride → 2-Bromo-1-(2,4-difluorophenoxy)-4-nitrobenzene

温度

110 °C

A mixture of 2-bromo-1-fluoro-4-nitrobenzene (15 g, 68 mmol), 2,4-difluorophenol (7.82 ml, 82 mmol), and cesium carbonate (26.7 g, 82 mmol) in dimethylsulfoxide (75 mL) was heated to 110° C. for 1 hour. The reaction mixture was cooled to ambient temperature and water (1000 mL) and saturated aqueous sodium chloride (1000 mL) were added. The mixture was extracted with ethyl acetate (3×200 mL). The combined organics were washed with saturated aqueous sodium chloride, dried (anhydrous magnesium sulfate), filtered, and concentrated under reduced pressure to provide the title compound (22.5 g, quantitative).

1. temperatureThe reaction mixture was cooled to ambient temperature
2. extractionThe mixture was extracted with ethyl acetate (3×200 mL)
3. washThe combined organics were washed with saturated aqueous sodium chloride
4. dry with materialdried (anhydrous magnesium sulfate)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure

ORDレコード

ord-79fd50099c3143bd8a393ca065c1eeaf

出典データセット

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09296741B2