Cyclohexylamine → 3-Bromo-4-(cyclopropylmethylamino)benzenesulfonamide

反応式

[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4]CC1.[Br:8][C:9]1[CH:10]=[C:11]([S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][C:14]=1F>>[Br:8][C:9]1[CH:10]=[C:11]([S:16]([NH2:19])(=[O:18])=[O:17])[CH:12]=[CH:13][C:14]=1[NH:7][CH2:1][CH:6]1[CH2:4][CH2:5]1

参加物

反応物 2

HCID 7965Cyclohexylamine

HCID 790405443-Bromo-4-fluorobenzenesulfonamide

生成物 1

HCID 437457443-Bromo-4-(cyclopropylmethylamino)benzenesulfonamide

実験手順

Example 238a was prepared according to the procedure used for the preparation of Example 96a, substituting cyclopropylmethanamine for cyclohexanamine, and 3-bromo-4-fluorobenzenesulfonamide for Example 86a, respectively, to provide the title compound.

後処理

customExample 238a was prepared
customused for the preparation of Example 96a

出典と根拠

ORDレコード: ord-2592102e6af74f11bfbd7a8c9b2158b2
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09296741B2

反応ノート

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