Dimethylamine → (RS)-4-chloro-N,N-dimethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

HRID 930979ノート

反応式

HRID 930979 の反応式
[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([OH:17])=O)[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:18][NH:19][CH3:20]>>[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([N:19]([CH3:20])[CH3:18])=[O:17])[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1

参加物

3

反応物 2

HCID 674DimethylamineHCID 179900774-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid

生成物 1

HCID 90014855(RS)-4-chloro-N,N-dimethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

実験手順

2.00 g (7.44 mmol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using N-methylmethanamine to give after working up and purification 1.68 g (76%) of the title compound.

後処理

  1. customto give
  2. custompurification 1.68 g (76%) of the title compound

出典と根拠

ORDレコード
ord-ba1705c666b94344a39477ae7d5df091
出典データセット
uspto-grants-2016_03
特許番号
US09296757B2

反応ノート

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