1,2-Ethanediamine, N1,N1-dimethyl-N2-(phenylmethyl)- → (RS)-N-benzyl-4-chloro-N-[2-(dimethylamino)ethyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

HRID 930992ノート

反応式

HRID 930992 の反応式
[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([OH:17])=O)[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH2:18]([NH:25][CH2:26][CH2:27][N:28]([CH3:30])[CH3:29])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([N:25]([CH2:26][CH2:27][N:28]([CH3:30])[CH3:29])[C:15]([CH:13]1[CH2:12][CH2:11][C:10]2[C:3]3[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=3[S:8][C:9]=2[CH2:14]1)=[O:17])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

3

反応物 2

HCID 660291,2-Ethanediamine, N1,N1-dimethyl-N2-(phenylmethyl)-HCID 179900774-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid

生成物 1

HCID 90014642(RS)-N-benzyl-4-chloro-N-[2-(dimethylamino)ethyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

実験手順

300 mg (1.12 mmol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using N′-benzyl-N,N-dimethylethane-1,2-diamine to give after working up and purification 152 mg (32%) of the title compound.

後処理

  1. customto give
  2. custompurification 152 mg (32%) of the title compound

出典と根拠

ORDレコード
ord-db863381082d4c83bdd2fe98879c3b52
出典データセット
uspto-grants-2016_03
特許番号
US09296757B2

反応ノート

読み込み中…