Bromine → 6-Amino-5-bromopyridine-3-carbonitrile

HRID 931040

反応式

HRID 931040 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[Br:10]Br>C(O)(=O)C>[NH2:1][C:2]1[C:9]([Br:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 24408BromineHCID 8182602-Amino-5-cyanopyridine

生成物 1

HCID 14912506-Amino-5-bromopyridine-3-carbonitrile

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 6-aminonicotinonitrile (5.0 g) in acetic acid (50 mL) was added bromine (4.3 mL) under ice-cooling. The reaction mixture was stirred at room temperature for 3 days, and the precipitate was collected by filtration. The obtained solid was suspended in ethyl acetate and IPE, and collected by filtration to give the title compound (8.2 g).

後処理

  1. temperaturecooling
  2. filtrationthe precipitate was collected by filtration
  3. filtrationIPE, and collected by filtration

出典と根拠

ORDレコード
ord-c37ee5a966f84b3ba9f10a38389ad20d
出典データセット
uspto-grants-2016_03
特許番号
US09296746B2

関連ノート

読み込み中…