Sodium ethoxide → Ethyl 6-cyclopropylpyrazine-2-carbimidate

HRID 931107ノート

反応式

HRID 931107 の反応式
[O-:1][CH2:2][CH3:3].[Na+].[CH:5]1([C:8]2[N:13]=[C:12]([C:14]#[N:15])[CH:11]=[N:10][CH:9]=2)[CH2:7][CH2:6]1>C(O)C>[CH:5]1([C:8]2[N:13]=[C:12]([C:14](=[NH:15])[O:1][CH2:2][CH3:3])[CH:11]=[N:10][CH:9]=2)[CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 898540196-Cyclopropylpyrazine-2-carbonitrile

生成物 1

HCID 89853280Ethyl 6-cyclopropylpyrazine-2-carbimidate収率 126.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium ethoxide (140 mg, 2.06 mmol) was added to a solution of 6-cyclopropylpyrazine-2-carbonitrile (150 mg, 1.03 mmol) in ethanol (6 mL) at room temperature. The reaction mixture was stirred at room temperature for 1 h. The solvent was removed under reduced pressure. The residue was partitioned between water and ethyl acetate. The organics were dried over sodium sulfate and concentrated under reduced pressure to afford the title compound (250 mg). MS (ES+) (M+H) 192.1012

後処理

  1. customThe solvent was removed under reduced pressure
  2. customThe residue was partitioned between water and ethyl acetate
  3. dry with materialThe organics were dried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ba63df32974e4e66958fbfae49e03872
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

反応ノート

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