Sodium ethoxide → HCID 117966492、化合物
反応式
[C:1]([C:3]1[CH:4]=[C:5]([S:9]([NH:12][CH3:13])(=[O:11])=[O:10])[CH:6]=[N:7][CH:8]=1)#[N:2].[O-:14][CH2:15][CH3:16].[Na+]>C(O)C>[CH3:13][NH:12][S:9]([C:5]1[CH:6]=[N:7][CH:8]=[C:3]([CH:4]=1)[C:1](=[NH:2])[O:14][CH2:15][CH3:16])(=[O:11])=[O:10]参加物
4
実験手順
To a solution of 5-cyano-N-methylpyridine-3-sulfonamide (0.1 g, 0.5 mmol) in ethanol was added sodium ethoxide (0.03 g, 0.55 mmol). After 2 h, the mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was concentrated under reduced pressure to afford ethyl 5-(N-methylsulfamoyl)nicotinimidate (120 mg) as an off-white solid. The material was used without further purification. MS (ES+APCI) 244.0; LCMS retention time: 3.047 min (Method I).
後処理
- concentrationthe mixture was concentrated under reduced pressure
- customThe residue was partitioned between ethyl acetate and water
- concentrationThe organic layer was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e987897b24a049ceb51b7ca4a0a6b1d0
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09296745B2
反応ノート
読み込み中…