Sodium ethoxide → HCID 89853752、化合物

HRID 931138

反応式

HRID 931138 の反応式
[CH:1]1([C:4]2[CH:5]=[N:6][CH:7]=[C:8]([CH:11]=2)[C:9]#[N:10])[CH2:3][CH2:2]1.[O-:12][CH2:13][CH3:14].[Na+]>C(O)C>[CH:1]1([C:4]2[CH:5]=[N:6][CH:7]=[C:8]([CH:11]=2)[C:9](=[NH:10])[O:12][CH2:13][CH3:14])[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 574196235-Cyclopropylnicotinonitrile

生成物 1

HCID 89853752HCID 89853752、化合物収率 76.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 5-cyclopropylnicotinonitrile (0.45 g, 3.1 mmol) in ethanol was added sodium ethoxide (0.212 g, 3.1 mmol). The reaction mixture was stirred at room temperature for 12 h. The solvent was removed under reduced pressure, and the residue was partitioned between water and ethyl acetate. The organic layer was concentrated under reduced pressure to afford the title compound (0.45 g) which was used without further purification. MS (ES+APCI) (M+H) 191.2; LCMS retention time 1.149 min (Method L1).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was partitioned between water and ethyl acetate
  3. concentrationThe organic layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-03f382616c464bf09188db30f5a8de75
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

関連ノート

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