Sodium ethoxide → ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate

HRID 931148ノート

反応式

HRID 931148 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10]#[N:11])[CH2:9][CH2:8]2)[CH:6]=1.[O-:12][CH2:13][CH3:14].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10](=[NH:11])[O:12][CH2:13][CH3:14])[CH2:8][CH2:9]2)[CH:6]=1

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 898536581-(4-Chloropyrazol-1-yl)cyclopropane-1-carbonitrile

生成物 1

HCID 117966385ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

To a solution of 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbonitrile (17.3 g, 103 mmol) in ethanol (50 mL) was added sodium ethoxide (prepared from 3.2 g, 139 mmol of sodium metal dissolved in 150 mL of ethanol). The reaction mixture was stirred at 70° C. for 2 h to afford ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate which was used for the next step without further purification. An aliquot of the solution was concentrated for analysis: 1H NMR (400 MHz, CDCl3): δ 1.25 (t, 3H), 1.46 (q, 2H), 1.73 (q, 2H), 4.15 (q, 2H), 7.51 (s, 1H), 7.52 (s, 1H).

出典と根拠

ORDレコード
ord-791bc05e48f644d49b4874cd539ae6aa
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

反応ノート

読み込み中…