Hydrochloric Acid → (-)-Nipecotic acid

HRID 931192ノート

反応式

HRID 931192 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1)=O)(C)(C)C.Cl>ClCCl>[NH:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 6435161-(1,1-Dimethylethyl) (3R)-1,3-piperidinedicarboxylate

生成物 1

HCID 1796510(-)-Nipecotic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
30 °C

実験手順

To (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (7.0 mmol) was added dichloromethane (48 mL) followed by hydrochloric acid (4M, 16 mL). The reaction mixture was stirred at 30° C. for 2 h. The solvent was removed under reduced pressure to afford (R)-piperidine-3-carboxylic acid which was used without further purification.

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-075cfefe530742c9a103d29b5ed0a298
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

反応ノート

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