Hydrochloric Acid → (-)-Nipecotic acid

HRID 931196ノート

反応式

HRID 931196 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1)=O)(C)(C)C.Cl>ClCCl.O1CCOCC1>[NH:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([OH:16])=[O:15])[CH2:9]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 6435161-(1,1-Dimethylethyl) (3R)-1,3-piperidinedicarboxylate

生成物 1

HCID 1796510(-)-Nipecotic acid

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
30 °C

実験手順

To a solution of (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (12.25 mmol) in dichloromethane (84 mL) was added a solution of hydrogen chloride in 1,4-dioxane (28 mL, 4M). The reaction mixture was stirred at 30° C. for 2 h. The solvent was removed under reduced pressure to afford (R)-piperidine-3-carboxylic acid which was used without further purification.

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-5fd8378b65ea47ea994e7fedc7b081c9
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

反応ノート

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