Hydrochloric Acid → cis-N,N,4-trimethylpiperidine-3-carboxamide hydrochloride

HRID 931274ノート

反応式

HRID 931274 の反応式
[CH3:1][N:2]([CH3:19])[C:3]([C@H:5]1[C@@H:10]([CH3:11])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:20]>CCOCC>[ClH:20].[CH3:1][N:2]([CH3:19])[C:3]([C@H:5]1[C@@H:10]([CH3:11])[CH2:9][CH2:8][NH:7][CH2:6]1)=[O:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 131735161cis-Tert-butyl 3-(dimethylcarbamoyl)-4-methylpiperidine-1-carboxylate

生成物 1

HCID 117966589cis-N,N,4-trimethylpiperidine-3-carboxamide hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To cis-tert-butyl 3-(dimethylcarbamoyl)-4-methylpiperidine-1-carboxylate (0.3 g, 1.12 mmol) was added a solution of hydrogen chloride in ether. The mixture was stirred for 30 min, and then was concentrated under reduced pressure to afford cis-N,N,4-trimethylpiperidine-3-carboxamide hydrochloride (0.16 g) as a white solid. The material was used without further purification.

後処理

  1. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-378b8cbdea6b4728924d6a55259f2a33
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

反応ノート

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