4-Methylnicotinic acid → 4-Methylpiperidine-3-carboxylic acid

HRID 931300

反応式

HRID 931300 の反応式
[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[CH:4][CH:3]=1>C(O)(=O)C.[Pt]=O>[CH3:1][CH:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH:7]1[C:8]([OH:10])=[O:9]

参加物

4

反応物 1

HCID 2291634-Methylnicotinic acid

生成物 1

HCID 136586094-Methylpiperidine-3-carboxylic acid収率 114.9%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒

実験手順

4-Methylnicotinic acid (5.0 g, 36.46 mmol) in acetic acid (40 mL) was added to a wet solution of platinum oxide (500 mg) under a nitrogen atmosphere. The suspension was hydrogenated under a hydrogen atmosphere (200 PSI) at room temperature for 18 h. The mixture was filtered through a pad of Celite under nitrogen and the filtrate was concentrated under reduced pressure to afford 4-methylpiperidine-3-carboxylic acid (6.0 g). The material was used without further purification.

後処理

  1. customat room temperature
  2. customfor 18 h
  3. filtrationThe mixture was filtered through a pad of Celite under nitrogen
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-96e156b0bb31468b9b914d462b6292dd
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

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