Hydrochloric Acid → (R)-morpholin-2-yl(pyrrolidin-1-yl)methanone hydrochloride
反応式
[ClH:1].[N:2]1([C:7]([C@@H:9]2[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3]1>O1CCOCC1>[ClH:1].[NH:11]1[CH2:12][CH2:13][O:14][C@@H:9]([C:7]([N:2]2[CH2:6][CH2:5][CH2:4][CH2:3]2)=[O:8])[CH2:10]1参加物
4
実験手順
A solution of hydrogen chloride in 1,4-dioxane (20 mL) was added to a solution of (R)-tert-butyl 2-(pyrrolidine-1-carbonyl)morpholine-4-carboxylate (0.62 g, 2.1 mmol) in \ 1,4-dioxane (5 mL). The reaction mixture was stirred at room temperature for 3 h. The solvent was removed under reduced pressure and the resulting crude material was triturated with diethyl ether to afford (R)-morpholin-2-yl(pyrrolidin-1-yl)methanone hydrochloride (0.4 g).
後処理
- customThe solvent was removed under reduced pressure
- customthe resulting crude material was triturated with diethyl ether
出典と根拠
- ORDレコード
- ord-777cb736477e4007a178d637ae411ac6
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09296745B2
反応ノート
読み込み中…