Potassium Hydroxide → 5-(((4-Methoxybenzyl)-oxy)methyl)furo[2,3-b]pyridine-2-carboxylic acid

HRID 931387ノート

反応式

HRID 931387 の反応式
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][O:8][CH2:9][C:10]2[CH:11]=[C:12]3[CH:18]=[C:17]([C:19](N(C)C)=[O:20])[O:16][C:13]3=[N:14][CH:15]=2)=[CH:5][CH:4]=1.[OH-:26].[K+]>CO.O>[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][O:8][CH2:9][C:10]2[CH:11]=[C:12]3[CH:18]=[C:17]([C:19]([OH:26])=[O:20])[O:16][C:13]3=[N:14][CH:15]=2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 900505425-(((4-Methoxybenzyl)-oxy)-methyl)-N,N-dimethylfuro[2,3-b]pyridine-2-carboxamide

生成物 1

HCID 900505445-(((4-Methoxybenzyl)-oxy)methyl)furo[2,3-b]pyridine-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

In a sealed tube, a mixture of a solution of 5-(((4-methoxybenzyl)-oxy)-methyl)-N,N-dimethylfuro[2,3-b]pyridine-2-carboxamide (2.4 g, 7.1 mmol) in methanol (28 mL) and a solution of potassium hydroxide (0.79 g, 14 mmol) in water (7 mL) was heated at reflux for 1 h. After cooling to ambient temperature, the reaction mixture was partitioned between saturated aqueous citric acid solution and ethyl acetate. The organic layer was dried over sodium sulfate, and concentrated to give the title compound. MS: m/z=314.2 (M+1).

後処理

  1. temperatureat reflux for 1 h
  2. customthe reaction mixture was partitioned between saturated aqueous citric acid solution and ethyl acetate
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-fc5c552267f14a2384864584ef4e423a
出典データセット
uspto-grants-2016_03
特許番号
US09296750B2

反応ノート

読み込み中…